Where to Buy Enzyme Cleaners: Walmart, Home Depot, Amazon

You can buy enzyme cleaners at Walmart, Home Depot, Target, Amazon, Lowe’s, and most pet stores. Walmart has the widest in-store selection. Amazon has the best prices on multi-packs. Home Depot carries commercial-strength options you won’t find elsewhere. We checked each store’s current inventory and prices so you don’t have to.

If you’re not sure what enzyme cleaners are or why you’d want one, start there. This guide assumes you’ve already decided to buy and just need to know where.

Enzyme cleaners at Walmart

Walmart carries the widest in-store selection of enzyme cleaners among brick-and-mortar retailers. You’ll find products in two sections of the store.

Where to look:

• Cleaning supplies aisle (near laundry detergent): general-purpose enzyme cleaners
• Pet supplies section: pet-specific enzyme cleaners and stain removers

Brands typically in stock:

• Nature’s Miracle enzyme cleaner (multiple formulas)
• Resolve Pet Expert stain remover
• Rocco & Roxie enzyme cleaner (select locations)
• OxiClean Versatile Stain Remover (enzyme-based formula)
• Great Value brand (Walmart’s store brand, enzyme-based options)

Price range: $5-$15 for standard sizes (at time of writing)

Online vs. in-store: Walmart.com has a wider selection than physical stores. Many products are available for same-day pickup or next-day delivery. Check online inventory for your local store before driving there to avoid wasted trips. The EWG cleaning products database is a good resource for comparing ingredient safety across brands.

Best for: Budget shoppers and one-stop convenience. If you need an enzyme cleaner today and don’t want to wait for shipping, Walmart is usually the fastest option.

For a detailed look at one of Walmart’s most popular enzyme cleaners, see our Nature’s Miracle review.

Enzyme cleaners at Home Depot

Home Depot’s enzyme cleaner selection is smaller than Walmart’s but skews toward commercial-strength products. If you need something heavy-duty for a tough job, this is where to look.

Where to look:

• Cleaning products aisle, often near janitorial supplies and mops

Brands typically in stock:

• Zep commercial enzyme cleaner (available in gallon sizes)
• Nature’s Miracle enzyme cleaner (limited selection)
• Kids ‘N’ Pets stain remover
• CLR brand enzyme formulas
• Bio-Clean enzyme drain cleaner

Price range: $8-$25 (at time of writing, skews higher due to commercial products)

Best for: Tougher jobs, commercial-grade cleaning, and drain maintenance. Home Depot carries more heavy-duty enzyme cleaners than Walmart or Target, including gallon jugs of Zep that you won’t find at most other retailers.

If you’re looking for drain-specific products, check our roundup of the best enzyme drain cleaners.

Enzyme cleaners at Target

Target’s selection falls between Walmart and Home Depot. It’s a solid option if you prefer eco-friendly brands or want to combine enzyme cleaner shopping with a regular Target run.

Where to look:

• Household cleaning aisle
• Pet aisle

Brands typically in stock:

• Nature’s Miracle enzyme cleaner
• Resolve Pet Expert stain remover
• Puracy cleaning products (eco-friendly brand, strong Target selection)
• Method brand (select enzyme formulas)

Price range: $6-$16 (at time of writing)

Best for: Eco-conscious shoppers and same-day pickup. Target Circle deals occasionally offer 10-15% off cleaning products, which can make Target the cheapest option for a specific product on any given week. You can also check the EPA Safer Choice list to find products that meet federal safety standards.

Enzyme cleaners on Amazon

Amazon has the widest selection of enzyme cleaners of any retailer, period. Every major brand plus specialty products that never show up in physical stores.

Brands available:

• Nature’s Miracle (full product line, every formula)
• Rocco & Roxie enzyme cleaner
• Anti Icky Poo enzyme cleaner
• Angry Orange enzyme cleaner
• Bio-Clean enzyme drain cleaner
• Bubbas Super Steamer
• Dozens of smaller and niche brands not carried in retail stores

Price range: $8-$30 (at time of writing, multi-packs and Subscribe & Save offer the best per-ounce price)

Best for: Widest selection, bulk buying, and hard-to-find products. If you want a specific formula (cat-specific, drain-specific, commercial-grade), Amazon almost certainly carries it.

Subscribe & Save: Most enzyme cleaners qualify for Amazon’s Subscribe & Save program, which takes 5-15% off the price. Set the delivery interval, get the discount, and cancel or adjust anytime.

For our top picks among Amazon’s selection, see our guides to the best enzyme cleaners for cat urine and the best pet stain and odor removers.

Other retailers that carry enzyme cleaners

If the big four don’t work for you, several other stores stock enzyme cleaners.

Lowe’s

Lowe’s carries a similar selection to Home Depot, focused on commercial and janitorial enzyme cleaners. Zep and CLR brands are usually available. Check the cleaning aisle near mops and buckets. In-store selection is limited, but Lowes.com has more options.

Pet stores (Petco, PetSmart, Chewy)

Pet stores have the best selection of pet-specific enzyme cleaners. That makes sense since pet messes are the primary use case.

• Petco and PetSmart carry Nature’s Miracle, Rocco & Roxie, and their own store-brand enzyme cleaners
• Chewy.com often has the lowest online prices on pet enzyme cleaners, with auto-ship discounts that rival Amazon’s Subscribe & Save
• Staff at pet stores can usually point you to the right product for your specific pet issue. The ASPCA also has guidance on pet-safe cleaning products

Grocery stores (Kroger, Safeway, etc.)

Grocery stores carry a limited selection, usually just Nature’s Miracle or Resolve in the pet aisle or cleaning aisle. Prices tend to be higher per ounce than big box stores. Grocery stores work in a pinch but aren’t the best option for value.

Price comparison across retailers

Prices vary by retailer, and the cheapest option depends on which product you want and how much you’re buying. Here’s a general comparison based on our research at time of writing.

Key takeaways from the price data:

• Walmart and Amazon are usually within $1 of each other for the same product
• Home Depot is cheapest for commercial Zep products in gallon sizes
• Amazon wins on multi-packs (buying 2-3 bottles at once saves 15-25% per unit)
• Target’s prices are slightly higher but Target Circle deals close the gap periodically

Tips for getting the best deal

A few strategies can save you money regardless of where you shop.

• Buy multi-packs or gallon sizes for the lowest per-ounce price. If you have pets, you’ll use enzyme cleaner regularly enough to justify buying in bulk.
• Check manufacturer websites for coupons. Nature’s Miracle and Resolve both run periodic promotions on their sites.
• Use Amazon Subscribe & Save for 5-15% off recurring orders. Even if you only order once, the discount applies to the first delivery.
• Watch for Walmart rollback prices. These often beat Amazon for popular brands like Nature’s Miracle.
• Target Circle offers occasionally include 10-15% off cleaning products.
• Don’t pay for overnight shipping. Enzyme cleaners aren’t urgent purchases most of the time. Keep one bottle on hand so you’re never scrambling.

For our product recommendations broken down by use case, see our guide to best pet stain and odor removers. And for drain-specific products available at Home Depot and Amazon, check out our Green Gobbler review.

Wrapping up

Walmart is the best bet if you need an enzyme cleaner today and want to walk into a store. Amazon is the best bet for selection, bulk pricing, and specialty products. Home Depot is where to go for commercial-strength formulas. Target works well for eco-friendly brands and occasional deals.

Whichever store you choose, check the product’s ingredient list to make sure it contains the right enzymes for your job. Protease for protein-based stains (urine, blood, food). Lipase for fat-based stains (vomit, grease). Both for the toughest messes. For help choosing, see our best enzyme carpet cleaners list or our eco-friendly enzyme cleaners roundup.

Keep a bottle on hand before you need it. Fresh stains are far easier to clean than old ones, and having enzyme cleaner ready means you can start treating a mess within minutes instead of making an emergency store run.